Arthritis Rheumatol 2018;70(Suppl 10). UCB.  |  2 Data on File, Mallinckrodt, 2019. Google Scholar Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial. Abstract 1482. Secondary outcomes and safety were also assessed. 6:214. doi: 10.3389/fmed.2019.00214. Deodhar A, van der Heijde D, Gensler LS, Kim TH, Maksymowych WP, Østergaard M, Poddubnyy D, Marzo-Ortega H, Bessette L, Tomita T, Leung A, Hojnik M, Gallo G, Li X, Adams D, Carlier H, Sieper J; COAST-X Study Group. Citation: Zhang J-R, Pang D-D and Dai S-M (2019) Non-steroidal Anti-inflammatory Drugs Are Unlikely to Inhibit Radiographic Progression of Ankylosing Spondylitis: A Systematic Review. ACR/ARP 2019 rotated-square. HHS Manica SR, Sepriano A, Pimentel-Santos F, Gouveia N, Barcelos A, Branco JC, Bernardes M, Ferreira RM, Vieira-Sousa E, Barreira S, Vinagre F, Roque R, Santos H, Madeira N, Rovisco J, Daniel A, Ramiro S. Arthritis Res Ther.  |  Cimzia ® (certolizumab pegol) approved by FDA for treatment of adults with active ankylosing spondylitis [press release]. The incidence of PsA is ∼6 per 100,000 per year, and the prevalence is ∼1–2 per 1,000 in the general population. Li LY, Lu N, Lacaille D, Xie H, Esdaile J, Avina-Zubieta JA. SOURCES: Jones J et al. Safety profile of baricitinib for the treatment of rheumatoid arthritis up to 7 years: an updated integrated safety analysis. Kroon FP, van der Burg LR, Ramiro S, Landewé RB, Buchbinder R, Falzon L, van der Heijde D. Cochrane Database Syst Rev. Arthritis Rheumatol. Evaluating Inflammatory Versus Mechanical Back Pain in Individuals with Psoriatic Arthritis: A Review of the Literature. Response to baricitinib at 4 weeks predicts response at 12 and 24 weeks in patients with rheumatoid arthritis: results from two phase 3 studies. Epub 2019 Aug 21. Cardiovascular disease rotated-square. -, Braun J, Sieper J. Ankylosing spondylitis. 2019;71(Suppl 10):1894. Several studies have reported increased risk of infections with biologic use in patients with psoriasis [2, 4,5,6,7] and rheumatoid arthritis (RA) [2, 8,9,10,11,12].  |  [5]van Vollenhoven, et al . For a searchable version of these abstracts, please visit www.acrabstracts.org. Overall TEAEs for UPA and Active Comparators (E/100 PYs [95% CI]) ! 2019 ACR/ARP Annual Meeting Abstract Supplement. Abstract: Kulig P, et al. Arthritis Rheumatol. 10). Arthritis Rheumatol. 2019 Nov;71(11):1788-1800. doi: 10.1002/art.41032. Clin Rheumatol 2017;36:2667-71. 10). Arthritis Rheumatol. [Google Scholar] ... with computed tomography-based tool for the evaluation of joint counts and disease activity in patients with rheumatoid arthritis. Results: Marzo-Ortega H, Mease PJ, Rahman P, Navarro-Compán V, Strand V, Dougados M, Combe B, Wei JC, Baraliakos X, Hunter T, Sandoval D, Li X, Zhu B, Bessette L, Deodhar A. Rheumatol Ther. 2015 Oct;67 Suppl 10:1-4046. doi: 10.1002/art.39448. doi: 10.1093/rheumatology/keaa435. This site needs JavaScript to work properly. ACR/ARP 2019 rotated-square. 2019;71(9):1472-82. Myocardial inflammation, measured using 18-fluorodeoxyglucose positron emission tomography with computed tomography, is associated with disease activity in rheumatoid arthritis. Epub 2012 Feb 2. 2017. 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. FRI0408 Earlier treatment of non-radiographic axial spondyloarthritis with certolizumab pegol results in improved clinical outcomes. 2019; 71 (4):496–506. Approximately 10 days after getting your blood drawn, you can directly access your Vectra test report online by going to VectraScore.com and clicking on the myVectra™ link. Affiliations, Disposition of the patients. Arthritis Rheumatol. Arthritis Rheumatol. Arthritis Rheumatol. In this phase III randomized, double-blind, placebo-controlled trial, adult patients with an inadequate response to or intolerance of 1 or 2 TNFi and an established diagnosis of axial SpA (according to the Assessment of SpondyloArthritis international Society [ASAS] criteria for radiographic axial SpA, with radiographic sacroiliitis defined according to the modified New York criteria and ≥1 feature of SpA) were recruited and randomized 1:1:1 to receive placebo or 80-mg subcutaneous ixekizumab every 2 weeks (IXEQ2W) or 4 weeks (IXEQ4W), with an 80-mg or 160-mg starting dose. Of 2819 citations, we identified 10 articles [, , , , 12, , , , , ] which met predefined criteria, as summarized in Fig. 2016 ACR/ARHP Annual Meeting Abstract Supplement. J Rheumatol 1996;23:1866-71. Arthritis Rheumatol. 2012 Aug;110(4):485-9. doi: 10.1111/j.1464-410X.2011.10879.x. We recruited rheumatologists nationally to participate in moderated structured group teleconference discussions using the nominal group technique. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. JAK inhibitors rotated-square. Related content Arthritis Rheumatol 2019; 71 ACR/ARP 2019; Atlanta, Georgia, USA: 8–13 November. See this image and copyright information in PMC. 2019:1-13. Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis). In December 2018, Idorsia initiated a multiple-dose, efficacy and safety study with cenerimod for the treatment of adult patients with moderately to severely active, autoantibody-positive SLE. Arthritis Rheumatol. Arthritis Rheumatol. 2019;71(suppl 10… Authors Michael M Ward 1 , Atul Deodhar 2 , Elie A Akl 3 , Andrew Lui 4 , Joerg Ermann 5 , Lianne S Gensler … 2018, 36 (Suppl. 2019;71(suppl 10 2019;71(suppl 10). Arthritis Rheumatol. Background/Purpose: Non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) are considered part of the spectrum of axSpA. Arthritis Rheumatol. BJU Int. Selmi C, Cantarini L, Kivity S, Dagaan A, Shovman O, Zandman-Goddard G, Perricone C, Amital H, Toubi E, Shoenfeld Y. Autoimmun Rev. Inflammatory bowel disease and anterior uveitis in patients treated with ixekizumab for radiographic axial spondyloarthritis: results from two phase 3 studies through 52 weeks. Arthritis Rheumatol 2019;71 (Suppl.  |  rheumatoid arthritis in Quebec, Canada: a population-based study. 3 Data on File, Mallinckrodt, 2019. Furst D, Wan G, Liu J, Zhu J, Bartels-Peculis L, Panaccio M, Fleischmann R. Improved Patient-Reported Outcomes in Patients with Persistently Active Rheumatoid Arthritis Following Treatment with Repository Corticotropin Injection [abstract]. Arthritis Rheumatol. Introduction.  |  A recent systematic review found the studies to be of high heterogeneity, small in numbers, and yielding inconsistent results. Clipboard, Search History, and several other advanced features are temporarily unavailable. Amigues I, Tugcu A, Russo C, Giles JT, Morgenstein R, Zartoshti A, et al. Entheses – emerging concepts. Please enable it to take advantage of the complete set of features! Background/Purpose: Olokizumab (OKZ) is a new humanized monoclonal antibody targeting IL-6 1, 2. Guselkumab rotated-square. Arthritis Rheumatol. Treatment-emergent adverse events (AEs) with ixekizumab treatment were more frequent than with placebo. ACR/ARP 2019 rotated-square. Inflammatory bowel disease and anterior uveitis in patients treated with ixekizumab for radiographic axial spondyloarthritis: results from two phase 3 studies through 52 weeks. Benedetti D, et al. Kremer J, Dougados M, Genovese MC, Emery P, Yang L, de Bono S, et al. Arthritis Rheumatol. Conversion rates of abstracts presented at the Urological Society of Australia and New Zealand (USANZ) Annual Scientific Meeting into full-text journal articles. We evaluated GUS efficacy and safety in a Phase 3, double-blind, PBO-controlled trial in … Related topics. 2019;71(suppl 10), Abstract 781 Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial. Presented at: 2019 ACR/ARP Annual Meeting; November 8-13, 2019… Objective: Arthritis Rheumatol. Arthritis Rheumatol. Arthritis Rheumatol. Efuni E, Cytryn S, Boland P, Sandigursky S. Risk of immunotherapy related toxicity in patients with rheumatoid arthritis [abstract 1339]. Arthritis Rheumatol. Arthritis Rheumatol. One death was reported (IXEQ2W group). A Multicenter Randomized Study in Early Rheumatoid Arthritis to Compare Active Conventional Therapy versus Three Biological Treatments: 24 Week Efficacy and Safety Results of the NORD-STAR Trial ... Kim Hørslev-Petersen 8, Till Uhlig 9, Gerdur Grondal 10, Mikkel Østergaard 11, Marte Heiberg 2, Jos Twisk 12, ... Arthritis Rheumatol. Research on the effect of psoriatic arthritis (PsA) on bone mineral density (BMD) is inconsistent. At week 16, significantly higher proportions of IXEQ2W patients (n = 30 [30.6%]; P = 0.003) or IXEQ4W patients (n = 29 [25.4%]; P = 0.017) had achieved an ASAS40 response versus the placebo group (n = 13 [12.5%]), with statistically significant differences reported as early as week 1 with ixekizumab treatment. 9. Patient-reported outcomes (PROs) aid in rheumatoid arthritis (RA) management, but it is not well understood which measures would be most relevant to the rheumatologists for making treatment decisions. GO TO SECTION. Safety profile of baricitinib for the treatment of rheumatoid arthritis up to 7 years: an updated integrated safety analysis. Arthritis Rheumatol 2016;68:282–98. Statistically significant improvements in disease activity, function, quality of life, and spinal magnetic resonance imaging-evident inflammation were observed after 16 weeks of ixekizumab treatment versus placebo. USA.gov. USA.gov. To investigate the efficacy and safety of ixekizumab in patients with active radiographic axial spondyloarthritis (SpA) and prior inadequate response to or intolerance of 1 or 2 tumor necrosis factor inhibitors (TNFi). NLM Authors Roy Fleischmann 1 , Aileen L Pangan 2 , In-Ho Song 2 , Eduardo Mysler 3 , Louis Bessette 4 , … 2019; 71 (suppl 10). 2019;71(suppl 10… Lancet. Arthritis Rheumatol. Cardiovascular disease rotated-square. 2019; 71 (suppl 10). 2020 Jan 4;395(10217):53-64. doi: 10.1016/S0140-6736(19)32971-X. Mallinckrodt ARD LLC. Upadacitinib rotated-square. Related topics. Arthritis Rheumatol. ACR/ARP 2019 … Upadacitinib rotated-square. 2019; 71 (suppl 10). 2019;71(suppl 10). Arthritis Rheumatol. Arthritis Rheumatol. [4]Sieper J, … The primary end point was 40% improvement in disease activity according to the ASAS criteria (ASAS40) at week 16. Trial registration: Arthritis Rheumatol 2019; 71 Arthritis Rheumatol 2019; 71 (suppl 10) ACR/ARP 2019; Atlanta, Georgia, USA: 8–13 November. 2019;71(suppl 10… A fifty-two-week, randomized, placebo-controlled trial of certolizumab pegol in nonradiographic axial spondyloarthritis. 2015 Jul 17;(7):CD010952. Serious AEs were similar across treatment arms. Arthritis Rheumatol. 2019;71(suppl 10), Abstract 1817; and Foley C et al. 2017 ACR/ARHP Annual Meeting Abstract Supplement. 2019;71(suppl 10). Arthritis Rheumatol 2019; 71 (suppl 10) ACR/ARP 2019; Atlanta, Georgia, USA: 8–13 November. Clinical and biological changes in rheumatoid arthritis patients exposed to an anti-inflammatory diet [abstract]. 2019;71(suppl 10… High dimensional flowcytometric profiling distinguishes psoriasis and psoriatic arthritis [abstract 1912]. [3]Langley RG, et al. DMARDs rotated-square. Lancet 2017;390:73–84. Kvien T, Glennås A, Knudsrød O, Smedstad L. The validity of self-reported diagnosis of rheumatoid arthritis: results from a population survey followed by clinical examinations. Growth and development of patients with polyarticular-course juvenile idiopathic arthritis … Entheses are tendons or ligaments that attach to the bone. Epub 2019 Dec 5. Arthritis Rheumatol. Arthritis Rheumatol. 2015 ACR/ARHP Annual Meeting Abstract Supplement. doi: 10.1002/14651858.CD010952.pub2. Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis: is the reason to switch relevant? 2019:1-13. Robinson PC, Sengupta R, Siebert S. Non-radiographic axial spondyloarthritis (nr-axSpA): advances in classification, imaging and therapy. The purpose of … In December 2018, Idorsia initiated a multiple-dose, efficacy and safety study with cenerimod for the treatment of adult patients with moderately to severely active, … 2019;71(10):1599-1613. Ixekizumab treatment for 16 weeks in patients with active radiographic axial SpA and previous inadequate response to or intolerance of 1 or 2 TNFi yields rapid and significant improvements in the signs and symptoms of radiographic axial SpA versus placebo. 2020 Dec;7(4):759-774. doi: 10.1007/s40744-020-00225-4. Arthritis Rheumatol. If you do not receive an email within 10 … © 2018 The Authors. Alfaleh MA, Alsaab HO, Mahmoud AB, Alkayyal AA, Jones ML, Mahler SM, Hashem AM. Epub 2019 Aug 28. Castellanos-Moreira R et al. Pages: 1-5420. Efuni E, Cytryn S, Boland P, Sandigursky S. Risk of immunotherapy related toxicity in patients with rheumatoid arthritis [abstract 1339]. 10. As a key manifestation, it has been included in the Classification Criteria for Psoriatic Arthritis (CASPAR) and as a treatment domain for the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment guidelines . Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L. Arthritis Care Res (Hoboken). Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force . Lancet 2007;369:1379–90. Risk of venous thromboembolism in rheumatoid arthritis patients initiating biologic and non-biologic DMARDs, a population-based study. Arthritis Rheumatol . National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019;71(suppl 10):abstract 2707. 1 There is also insufficient guidance on BMD testing in patients with PsA as per recent major clinical practice guidelines. Ann Rheum Dis 2017;76:978–91. Arthritis Rheumatol. Rheumatol Ther. Front Immunol. View this table: Table. Lancet 2019;393:2303-11. Related content Arthritis Rheumatol. Reducing or Maintaining the Dose of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis in Clinical Remission: A Randomized, Open‐Label Trial Raimon Sanmarti MD, … Sieper J, van der Heijde D, Dougados M, Maksymowych WP, Scott BB, Boice JA, Berd Y, Bergman G, Curtis S, Tzontcheva A, Huyck S, Weng HH. 2019;71(suppl 10): Abstract 930. JAK inhibitors rotated-square. [PMC free article] [Google Scholar] Arthritis Rheumatol. Volume 71, Issue S10. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. 2019; 71 (suppl 10). Methods: Arthritis Rheumatol 2019; 71 ACR/ARP 2019; Atlanta, Georgia, USA: 8–13 November. UL1 TR000371/TR/NCATS NIH HHS/United States, Reveille JD, Witter JP, Weisman MH. Presented at: 2019 ACR/ARP Annual Meeting; November 8-13, 2019… Baker NA, Barbour KE, Helmick CG, Zack MM, Al snih S. Arthritis and cognitive impairment in older adults. 2020 Dec;7(4):667-684. doi: 10.1007/s40744-020-00234-3. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin … Risk of venous thromboembolism in rheumatoid arthritis patients initiating biologic and non-biologic DMARDs, a population-based study. Arthritis Rheumatol 2018;70(Suppl 10). Export Citation(s) Export Citations. Arthritis Care Res (Hoboken) 2012;64:905–10. October 2019. Tapering and withdrawal of tocilizumab in patients with systemic juvenile idiopathic arthritis in inactive disease: results from an alternative dosing regimen in the TENDER study. HHS 2019;71(10):1599-1613. 2020 Aug 28;11:1986. doi: 10.3389/fimmu.2020.01986. 6. Treatment strategies in axial spondyloarthritis: what, when and how? Morand E, et al. Arthritis Rheumatol. 2019;71(suppl 10), Abstract 2722; Foley C et al. [4]Fleischmann, et al . Background/Purpose: Patients (pts) with RA have an approximate 2-fold increased risk of cardiovascular (CV) morbidity and mortality and of venous thromboembolic events (VTE)1,2. 2018 Dec 8;392(10163):2441-2451. doi: 10.1016/S0140-6736(18)31946-9. Therapeutic Advances in Musculoskeletal Disease 2019 10.1177/1759720X19864492 Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 2016; 68 (suppl 10) Smolen JS, Schöls M, Braun J, et al. Genovese M, Smolen J, Takeuchi T, et al. Arthritis | ACR/ARP 2019 … SOURCES: Jones J et al ® ( certolizumab pegol ) approved FDA., Cornejo GV, Berman a, Ermann J, Takeuchi T, et al evolving.... 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